• The expansion and maturation of mature ECs and EPCs requires

  2018-11-08

  

  The expansion and maturation of mature ECs and EPCs requires the addition of pro-angiogenic growth factors such as VEGF. With regards the translation of cell-based therapies into clinic, it is of interest to avoid the expensive and controversial use of recombinant growth factors. The supplementation

• br Materials and methods br Results

  2018-11-08

  

  Materials and methods Results There are a number of complex methods for the generation of neural subtypes from hESCs and iPSCs. In most of them, intact pluripotent colonies are first lifted, induced to form EBs, and then grown in the presence of lineage specific morphogens and growth factors t

• In our previous study we reported

  2018-11-08

  

  In our previous study, we reported a genetic diagnosis of a GT patient with two different mutations in the two ITGA2B alleles. Both mutations activated a same recessive intron splicing site and cause a 99-base deletion in IIb mRNA (Li et al., 2011). In the current study, we successfully established

• Although the detailed mechanisms underlying

  2018-11-08

  

  Although the detailed mechanisms underlying the increase in PDX1+NKX6.1+ cell induction in aggregation cultures remain unknown, this finding raises the possibility that pancreatic bud formation may be regulated by the molecules associated with contact-dependent cellular interactions, such as extrace

• This work was supported by the Elsa U Pardee Foundation

  2018-11-08

  

  This work was supported by the Elsa U. Pardee Foundation research grant, an American Heart Association grant #0765185B, the Wayne State University Cardiovascular Research Institute Isis Initiative award, and American Cancer Society Institutional Research Grant #11-053-01-IRG (to C.L.), and the Leuke

• For in vivo experiments we utilized transplantation of

  2018-11-08

  

  For in vivo experiments, we utilized transplantation of SHh-pretreated Gm-CD34+ abk rather than the co-administration of Gm-CD34+ cells (EPCs) and SHh protein or SHh gene transfer (Palladino et al., 2012) into ischemic hindlimbs, and could detect both EC marker and VSMC marker expressing cells, pos

• In our prior studies we showed that K

  2018-11-08

  

  In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer thrombopoietin receptor agonist through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG1

• Micro array data has been submitted to Gene Expression

  2018-11-08

  

  Micro-array data has been submitted to Gene Expression Omnibus with GEO accession number: GSE72118. Competing financial interests Acknowledgements Introduction Recent studies in the stem cell field have demonstrated that cell fate transition could be achieved by introducing lineage-specifi

• HSCs isolated by the set of markers which

  2018-11-08

  

  HSCs isolated by the set of markers which are Lin−/Sca-1+/C-kit+ (LSK) have been also reported to be heterogeneous (Osawa et al., 1996). Moreover, Sca-1 expression differs between mouse strains and therefore is not very effective to enrich HSCs (Spangrude and Brooks, 1993). Likewise, the SLAM family

• br Materials and methods br Results br Discussion Others

  2018-11-08

  

  Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e

• It has been hypothesized that

  2018-11-08

  

  It has been hypothesized that neurogenesis in DG may play an important role in learning and memory and especially in spatial memory (Deng et al., 2010; Jessberger et al., 2009; Piatti et al., 2013). In the present study, mice with AQ treatment showed an increased percentage of spontaneous alternatio

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Pluripotent human embryonic stem Plerixafor Supplier (hESCs) can differentiate into all somatic cells of the human body and hold tremendous potential for developmental biology, drug screening, and regenerative me

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Dopamine (DA) cell replacement for Parkinson’s disease (PD), using transplantation of human fetal ventral mesencephalic tissue to the striata of PD patients, has provided proof of principle that DA-neuron-rich grafts can survive long ter

• By performing selective molecular profiling with

  2018-11-08

  

  By performing selective molecular profiling with LMD, we were able to demonstrate that the expression of many pre- and postsynaptic molecules, including Bassoon, Piccolo, Synaptophysin, Synapsin, Synaptotagmin, Vglut1, Vglut2, Vgat, Gad65, Gad67, Psd95, Homer1, and Shank1, were observed in the engra

• clozapine-n-oxide Neurogenesis in the adult mammalian brain

  2018-11-08

  

  Neurogenesis in the adult mammalian clozapine-n-oxide occurs throughout life and has been clearly demonstrated at two locations under physiological conditions: the SVZ of the lateral ventricle and the subgranular zone (SGZ) of the DG in the hippocampus (Alvarez-Buylla and Lim, 2004). Several studie

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