• In addition to classical receptor targets such as

  2018-11-05

  

  In addition to ‘classical’ receptor targets such as EGFR (Roovers et al., 2007,2011; Schmitz et al., 2013; Omidfar et al., 2013), HER2 (Jamnani et al., 2012; Even-Desrumeaux et al., 2012), c-MET (Slordahl et al., 2013) and VEGFR (Behdani et al., 2012), nanobodies against new targets such as the DR5

• br Materials and methods br Results br Discussion

  2018-11-05

  

  Materials and methods Results Discussion In the search for drugs for human prion diseases, we conducted docking simulation using a DEGIMA supercomputer. Results from the in vitro and ex vivo drug screening revealed that NPR-053 and -056 significantly reduced PrPSc levels (Figs. 2 and 5). Al

• Although there is no clear association between narcolepsy an

  2018-11-05

  

  Although there is no clear association between narcolepsy and PLMs, some studies demonstrated the important role of hypocretin-1 in this ret pathway association . Alteration of the autonomic regulation, sleep fragmentation and increase in the PLMs prevalence might be present in patients with narcole

• Much work has been done previously in community

  2018-11-05

  

  Much work has been done previously in community-dwelling older adults on the relationship between the level of physical activity and sleeping. These studies have involved direct comparisons between physically fit and unfit groups [6,7], cross-sectional observational studies [8–11], and randomized co

• The most frequent reasons for indication of RP were

  2018-11-05

  

  The most frequent reasons for indication of RP were: snoring (76%), observed apneas (32%), sleepiness or poor sleep quality (74%), and snoring associated to arterial lipid metabolism pathway (AHT) 41% (Fig. 1). The Fig. 2 shows distribution according to anthropometric parameters. The polygraphic i

• The physiology of sleep wakefulness cycle may be

  2018-11-05

  

  The physiology of sleep-wakefulness pri-724 may be affected as a result of changes in ovarian hormone synthesis. The menopause and the reduction in the availability of endogenous estradiol, that occur within the climacteric, have been considered risk factors for SD. The effect could be directly infl

• br Discussion CPAP therapy has been considered the gold stan

  2018-11-05

  

  Discussion CPAP therapy has been considered the gold standard for treatment of OSAS in adults. However, despite the success potential of CPAP, non-adherence by patients remains a major problem [9]. Some publications have been critical regarding surgeries and their results [10]. Elshaug et al. (20

• In spite of the large

  2018-11-05

  

  In spite of the large number of assumptions made, both for calculation of the biofilm volume fraction in the resonator and for the model simulations, Fig. 13 clearly demonstrates that, in case of biofouling on the glass beads, the measured sensor response (shift in AF plot) is in the same direction

• br Conclusions In summary novel SERS active substrates were

  2018-11-05

  

  Conclusions In summary, novel SERS-active substrates were prepared by inert gas phase condensation technique using a Nanodep60 cluster deposition system. We used 2-Thienylboronic HMBA Linker as linker or bridge molecule that attached to the silver surface on one side and to the glucose molecule

• Oxysterols serve as endogenous ligands of liver

  2018-11-03

  

  Oxysterols serve as endogenous ligands of liver X receptors (LXRα (NR1H3)/LXRβ (NR1H2)) (Janowski et al., 1996). In addition to their established role in cholesterol metabolism (Janowski et al., 1999), LXRs also suppress inflammatory gene expression, thus controlling immune response and inflammation

• Volasertib The clear genetic link between breast

  2018-11-03

  

  The clear genetic link between breast cancer and the CCDC170 gene, and the earlier identification of another CCDC protein (MTCL1/CCDC165) that mediates the formation of a stable Golgi-derived microtubule network (Sato et al., 2014), provided a solid foundation for further exploration of the role of

• Concerning the dynamic parameters in

  2018-11-03

  

  Concerning the dynamic parameters in Fig. 1, all the trends can be represented by second grade polynomial functions, while regarding the dynamic parameters in Fig. 2 all the trends can be represented by a first grade polynomial function. Concerning the decrement factor of the temperature fT trend,

• As summarized in Table our primary aim was to quantify

  2018-11-03

  

  As summarized in Table 1, our primary aim was to quantify the test–retest reliability of a range of R-fMRI metrics in school-age children with and without ADHD. Several measures of test–retest reliability are available and have been used for R-fMRI (e.g., Thomason et al., 2011; Shehzad et al., 2009;

• br A view of late hippocampal development predictions

  2018-11-03

  

  A view of late hippocampal development: predictions One prediction is that children relying on cortical networks should require many more exposures for learning and retain less. An excellent example comes from word learning. Bergelson and Swingley (2012) report that by 6–9 months of age children

• Compared with a control group preschool and school aged chil

  2018-11-03

  

  Compared with a control group, preschool and school-aged children with SLI showed deficits in a lexical tone (/i2/–/i3/) discrimination task, and lexical tone discrimination sensitivity had additional predictive power regarding their overall language comprehension ability after adjustment for existi

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