• opiate receptors Using the highly sensitive TCF Lef H

  2018-10-24

  

  Using the highly sensitive TCF/Lef:H2B-GFP reporter, we demonstrate that Wnt/β-catenin signaling is transiently active during muscle regeneration, specifically in myoblasts 1 dpi. Our finding that myoblasts transiently transduce Wnt/β-catenin signals agrees with previous analyses of nuclear β-cateni

• br Materials and methods br Acknowledgments This work was

  2018-10-24

  

  Materials and methods Acknowledgments This work was supported by Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (grant numbers SAF2013-43005-R and SAF2016-76004-R). The authors thank INDEPF (Instituto de investigación y desarrollo social de enfermedades

• atp gamma s CXCR is a widely expressed

  2018-10-24

  

  CXCR4 is a widely expressed chemokine receptor that is essential for development, hematopoiesis, organogenesis, and vascularization (Busillo and Benovic, 2007). The CXCR4/SDF-1 axis is important in cardiac development as evidenced by the observed cardiac phenotype in knockout transgenic strains (Nag

• leukotriene receptor antagonists Here we present an algorith

  2018-10-24

  

  Here we present an algorithm, KeyGenes, that we have used on NGS data extracted from tissues of 21 different human fetal organs, both embryonic and extraembryonic (plus the maternal endometrium), from the first and second trimesters of development to determine a panel of classifier genes that would

• br Introduction The balance between hematopoietic stem

  2018-10-24

  

  Introduction The balance between hematopoietic stem cell (HSC) proliferation and quiescence is tightly regulated (He et al., 2009). Adult HSCs are usually quiescent, but their proliferation rates increase upon exposure to cytokines (Baldridge et al., 2010; Essers et al., 2009; Morrison et al., 19

• Previous studies reported that the introduction of KitW or

  2018-10-24

  

  Previous studies reported that the introduction of KitW41 or KitWv mutations into BALB-RG or NSG mice could render mouse HSCs uncompetitive to donor human HSCs (Cosgun et al., 2014; McIntosh et al., 2015). They also showed that human HSPCs injected at a high dose (5 × 104 to 3 × 105 CD34+ CB cells),

• trk receptor br Results We previously published a zebrafish

  2018-10-24

  

  Results We previously published a zebrafish model of g6pd deficiency that showed acute sensitivity to pro-oxidant challenge with robust ROS generation and significant erythroid cell death when tested in developing zebrafish (Patrinostro et al., 2013). The zebrafish is an advantageous model to stu

• br Introduction Mesenchymal stem stromal cells MSCs are

  2018-10-24

  

  Introduction Mesenchymal stem/stromal ribosomal s6 kinase (MSCs) are an excellent biological source for bone regenerative therapies, tissue engineering, and treatment of post-menopausal osteoporosis (Murphy et al., 2013; Steinert et al., 2012). Ex vivo expansion of autologous bone marrow stromal

• What is more intriguing is that non MNs undergo

  2018-10-24

  

  What is more intriguing is that non-MNs undergo degeneration earlier than MNs. This is demonstrated by the fact that loss of non-MNs is already obvious in the spinal cord segment that is distant from the injection site and has partial (ventral gray matter) integration by human astrocytes. Unlike the

• ekb-569 br Results br Discussion With the advent

  2018-10-24

  

  Results Discussion With the advent of hESCs (Thomson et al., 1998) and hiPSCs (Takahashi et al., 2007; Yu et al., 2007), our understanding of mechanisms underlying phenomena such as cellular dysfunction in neurological diseases has advanced greatly because these hPSCs are, at least in part, ca

• Indeed recent qualitative studies support

  2018-10-24

  

  Indeed, recent qualitative studies support the idea that discrimination exists against the poor in Canada for their poor oral health (Bedos, Levine & Brodeur, 2009; Ravitch & Riggan, 2012; Shankardass, Lofters, Kirst & Quiñonez, 2012; Vallittu, Vallittu & Lassila, 1996). Our study attempts to assess

• Another relevant approach role expansion theory suggests tha

  2018-10-24

  

  Another relevant approach, role expansion theory, suggests that men who undertake a greater number of social roles, such as household management and childcare, are able to access psychological and social resources that are protective for health (Barnett & Hyde, 2001). For example, men who can draw s

• Disclosure AZW is supported by R CA from

  2018-10-23

  

  Disclosure AZW is supported by R01CA178748-01 from the National Institutes of Health/National Cancer Institute and 1-U54-CA151652-01 from the National Institutes of Health Center for Nanotechnology Excellence. The author declared no conflicts of interest. Lung cancer is the leading cause of canc

• Despite this intriguing connection pre conditioning with SL

  2018-10-23

  

  Despite this intriguing connection, pre-conditioning with SL-LPS in the context of sepsis mortality has never been studied. Thus, we tested the bromodomain that SL-LPS pre-conditioning may exacerbate, instead of alleviate sepsis mortality in vivo. We employed the classical cecal ligation and punctur

• Finally in limited studies it has been suggested that the

  2018-10-23

  

  Finally, in limited studies it has been suggested that the presence or absence of any particular comorbid anxiety disorders may alter the pattern and prognosis of bipolar disorder. For instance, Pini et al. (1997) suggested three patterns in association with anxiety and affective disorder: (i) GAD w

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