• UV induced changes in the cornea are largely mediated

  2018-10-20

  

  UV-induced changes in the cornea are largely mediated by the up-regulation of pro-inflammatory cytokines such as interleukin (IL)1 (Corsini et al., 1997), IL6 (Di Girolamo et al., 2002), IL8 (Di Girolamo et al., 2002) and tumour necrosis factor alpha (TNFα) (Kennedy et al., 1997) which correlate to

• br Author contributions br Grant

  2018-10-20

  

  Author contributions Grant support The study received the Bardhan Research and Education Trust (BRET) (14345) support. Disclosures Acknowledgements Many thanks to the Bardhan Research and Education Trust (BRET) (14345) , which supports research into digestive diseases, for funding the w

• Most of the observed H

  2018-10-20

  

  Most of the observed H3K27me3 and H3K4me3 re-patterning and mRNA expression changes of cardiac genes were associated with the optimal reprogramming condition (MGT, Fig. 3). On the other hand, H3K27me3 deposition at fibroblast genes was observed mostly under the optimal reprogramming condition, while

• Using ESNPs to repair damaged tissue in neurodegenerative di

  2018-10-20

  

  Using ESNPs to repair damaged tissue in neurodegenerative diseases is an attractive option, as these aa utp are more readily obtained than fetal material. Recent work on the relationship between neural stem cells and blood vessels (reviewed in (Bjornsson et al., 2015) as well as our own transplant w

• Recently human umbilical cord hUC has been

  2018-10-20

  

  Recently, human umbilical cord (hUC) has been investigated as a source of tamoxifen citrate with stem/progenitor cell properties. hUC is a desirable source of stem/progenitor cells as it is routinely discarded after delivery, collection is non-invasive and an abundant number of cells are present in

• The following are the supplementary data related to this

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgments The authors wish to thank Dr. K. Inoue for the S100β/GFP-TG rats, Dr. A.F. Parlow and the NIDDK for the dihydrochloride Supplier against pituitary hormones, Dr. S. Tanaka at Shizuoka University for the antibody ag

• br Material and methods br Results br Discussion Pre

  2018-10-20

  

  Material and methods Results Discussion Pre-transplant myeloablation has been consistently seen to be associated with an increase in the number of adipocytes in the bone marrow (Snyder, 1965; Naveiras et al., 2009; Cao et al., 2011). These marrow adipocytes were considered as passive space

• Using the combination of a mitogen activated protein

  2018-10-20

  

  Using the combination of a mitogen-activated protein kinase kinase (MEK) inhibitor, PD0325901 (PD03), and a glycogen synthase kinase 3 (GSK3) inhibitor, CHIR99021 (CHIR), which will hereafter be referred to as 2i, mouse ESCs (mESCs) are maintained in a ground state (Ying et al., 2008). CHIR activate

• Although the present study focuses predominantly on keratino

  2018-10-20

  

  Although the present study focuses predominantly on keratinocytes, it has been known for many years that fibroblasts play an important role in wound healing and in remodeling the extracellular matrix. Thus, an ideal bioengineered graft will always need to incorporate fibroblasts as well as keratino

• Our data also provide information on the pathophysiology of

  2018-10-20

  

  Our data also provide information on the pathophysiology of FA itself. First, we found that the drastic acceleration of cell cycling observed in Fancd2 HSPCs is unique to this blood cell population. No order fluvastatin abnormalities were observed in mature hematopoietic lineages. Others have found

• Intestinal epithelial SCs IESCs are

  2018-10-20

  

  Intestinal epithelial SCs (IESCs) are roughly categorized as either quiescent or active IESCs based in part on the expression of specific markers, including LGR5, Olfm4, Ascl2, BMI1, MTERT, and LRIG1 (Barker et al., 2007; Montgomery et al., 2011; Powell et al., 2012; Sangiorgi and Capecchi, 2008). T

• tTA Tet Off exhibited high basal luciferase activity and mpC

  2018-10-20

  

  tTA2 (Tet-Off) exhibited high basal luciferase activity and mpCLOVER expression, similar to that of dox-induced rtTA-V10 (Figure 2D; Figure S2A4). mpCLOVER expression decreased with dox addition until it was undetectable at 5 days, and it rebounded 3 days after dox removal (Figures S2B4–S2D4). Lumin

• We have developed a protocol for the

  2018-10-20

  

  We have developed a protocol for the efficient differentiation of functional HLCs from hPSCs that does not require the addition of recombinant growth factors and is applicable to both hESCs and hiPSCs. During the development of the protocol, it came as a surprise to discover that pluripotent Tasquin

• Data generated from GSEA DAVID and gene hierarchical cluster

  2018-10-20

  

  Data generated from GSEA, DAVID and gene hierarchical clustering of sorted stem and committed progenitor cell transcriptomes provides an opportunity to explore processes that govern prostate stem cell biology, self-renewal and differentiation. One notable enrichment in active stem nucleoside analogs

• It is interesting that OB

  2018-10-20

  

  It is interesting that OB neurons produced from the transient Gli1-enriched subcallosal domain in juvenile mice mostly corresponded to sGCs, when they were derived from a region with active SHH signaling. It is possible that the relative levels of SHH signaling are adjusted in different domains. The

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