• br Discussion There are many reports on the effectiveness of

  2019-04-24

  

  Discussion There are many reports on the effectiveness of pacing therapy for hypertrophic obstructive cardiomyopathy. Fananapazir et al. reported that long-term right ventricular apical pacing improved both the left ventricular outflow tract gradient and subjective symptoms [3]. Maron et al. repo

• In the management of BrS patients it

  2019-04-24

  

  In the management of BrS patients, it is important to avoid or treat certain drugs or circumstances such as a febrile state, electrolyte disturbances (hyperkalemia and hypercalcemia), and the use of class Ia/Ic antiarrhythmic drugs, vagotonic agents, beta-adrenergic antagonists, tricyclic antidepres

• br Materials and methods br Results br Discussion

  2019-04-24

  

  Materials and methods Results Discussion Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most common type of primary bone malignancy [20]. Over the past few decades, the introduction of combinatorial chemotherapy has improved the 5-year overall survival rate of

• br Outstanding questions br Conflict of interest

  2019-04-24

  

  Outstanding questions Conflict of interest Acknowledgments This work was supported by the Dutch Cancer SocietyUL2015-7599 KWF (EZ). Platelets and cancer metastasis Blood platelets play a primary role in wound healing and hemostasis. Since the first observation made (on himself) by the s

• Additionally the selection for subcutaneous ICD

  2019-04-24

  

  Additionally, the selection for subcutaneous ICD implant is based on pre-implant electrographic body surface mapping. The sensing algorithm for this system depends on the surface elecrtrocardiogram (ECG) morphology, specifically the R-and T-wave amplitudes, R/T and R/P ratios, QRS duration and QT in

• br Conclusions and future perspectives br Conflict of intere

  2019-04-24

  

  Conclusions and future perspectives Conflict of interest Author’s contributions Introduction Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two opposing mechanisms involved in regulating the chemical and functional homeostasis of end

• Recently a reciprocal fusion between YPEL yippee

  2019-04-23

  

  Recently, a reciprocal fusion between YPEL5 (yippee-like 5) and PPP1CB (serine/threonine protein phosphatase-1 beta catalytic subunit) was described to be exclusively expressed in more than 90% of primary CLL samples [5] and not in control samples or samples from patients with other hematological ma

• br Hematopoietic cell transplantation HCT is generally recom

  2019-04-23

  

  Hematopoietic cell transplantation HCT is generally recommended for AML patients with intermediate or high risk cytogenetics, when the aim of treatment is curative. However, elderly patients are seldom offered a transplant mainly due to concerns regarding toxicity, despite the fact that the main

• In addition to the potential for adverse effects

  2019-04-23

  

  In addition to the potential for adverse effects of poor growth on brain outcomes in this cohort, the prevalence of iron deficiency was also alarmingly high. All the hospitals recommended iron supplements at discharge and throughout the intervention period, but levels of compliance could not be dete

• There are a number of reasons

  2019-04-23

  

  There are a number of reasons for this disparity: people with disabilities are disproportionately poor, lacking in access to education and employment, and excluded from social networks. Health-care facilities, equipment, and transportation are often inaccessible. But another significant factor is th

• We are in the midst of a

  2019-04-22

  

  We are in the midst of a paradigm shift for antenatal and intrapartum care: from focusing mainly on coverage to also considering quality as an essential component of improving health systems, as stated in the WHO vision on quality of care and other efforts. For intrapartum care, poor quality at faci

• Studies of strategies to reduce

  2019-04-22

  

  Studies of strategies to reduce greenhouse gas emissions and improve health in urban environments have shown the potential to achieve both environmental and health improvements. For example, modelled effects of low emission vehicles and increased walking and cycling in London and Delhi showed major

• Interpretation Patient centred medical education can improve

  2019-04-22

  

  Interpretation Patient-centred medical education can improve overall satisfaction and sustained disease-specific knowledge in patients in Uganda. Our results show that printed booklets are accepted by patients and feasible to implement in a LMIC outpatient setting. Funding Trishul Siddharthan recei

• Could new approaches to global

  2019-04-22

  

  Could new approaches to global nutrition lead to interventions that would make children grow tall without putting on excessive fat, as is the case for present-day piglets? Animal science has been addressing this issue for a long time, although with rigorous studies that cannot be conducted in humans

• Self reported health SRH is

  2019-04-22

  

  Self-reported health (SRH) is considered to be a valuable source of data on various aspects of general health. In fact, it is one of the most widely used indicators of health status in survey research, and is recommended by the World Health Organization. SRH can be influenced by individual determina

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