• The present work has implications for our thinking about

  2023-12-22

  

  The present work has implications for our thinking about the effects of antidepressant (e.g. SSRIs) use on maternal care in depressed mothers which consist of approximately 10–20% of all mothers (Gjerdingen and Yawn, 2007, Susser et al., 2016), and more than 40% of depressed mothers are prescribed w

• HT modulates cortical and hippocampal

  2023-12-22

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal Fmoc-Asp-OAll as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al.,

• The introduction of a pyrazole moiety

  2023-12-22

  

  The introduction of a pyrazole moiety into any position of the sterane core by cross-coupling reactions [13] or by Knorr construction from a CCC bis-electrophilic sterane precursor and an N,N binucleophile building block [17], [19] may serve as an example. Very few reports are to be found, however,

• Axl has been reported to mediate cell cell

  2023-12-22

  

  Axl has been reported to mediate cell-cell adhesion and sphere-growth [11], [18] and to be important for metastasis to secondary organs [12], [14], [20]. We found an Axl-dependent CCRCC-ability of sphere-formation and repopulation after non-adhesive growth. Axl-inhibited cells could not attach to ea

• MafB a member of the Maf protein

  2023-12-22

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in PRT 4165 with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages of

• br Introduction The process of mitosis

  2023-12-22

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the HMPL-013 resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in regulating th

• Our results suggest that plasma membrane and a containing

  2023-12-22

  

  Our results suggest that plasma membrane and a3-containing V-ATPases represent an important and novel target in the development of drugs to limit breast cancer metastasis. That knock-down of a3 has been shown to reduce metastasis of melanoma cells in an in vivo mouse model suggests that this role ma

• Protein protein interaction networks are

  2023-12-22

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• br Conclusion GroEL from RA CH was expressed

  2023-12-22

  

  Conclusion GroEL from RA-CH-1 was expressed and purified. The recombinant RaGroEL protein exhibited ATPase activity, which cooperated with GroES in ATP hydrolysis. Furthermore, the expression pattern of groEL revealed that groEL was up-regulated during stress response. Further studies are warrant

• br HIF Blockade in AA Therapy In lieu

  2023-12-21

  

  HIF-α Blockade in AA Therapy In lieu of the evidence supporting a central role for HIF-α signaling in tumor angiogenesis and CC pathobiology, significant efforts have focused on the discovery of small-molecule HIF-α inhibitors (for exhaustive compendia, see [28,44,45]). In brief, inhibitors vary

• saquinavir A Belgian review on perioperative management of d

  2023-12-21

  

  A Belgian review [9] (2011) on perioperative management of drugs recommends not using ACEI/ARBs due to the same reason. Another 2014 French [10] publication on the management of antihypertensive drugs in the perioperative period suggests withholding this medication before surgery even though they a

• br Materials and methods br Results

  2023-12-21

  

  Materials and methods Results Discussion The transcriptional activity of PGC-1α is regulated by a number of stimuli, exemplifying the range of settings in which mitochondrial biogenesis is induced. The mechanisms governing this regulation have been extensively studied and have been determin

• Previous studies have demonstrated that synaptic AMPARs can

  2023-12-21

  

  Previous studies have demonstrated that synaptic AMPARs can differ greatly in their mobility; some rapidly and constitutively hbv virus in and out of the synaptic membrane, while others remain somewhat stable in the synaptic membrane (Luscher et al., 1999, Luthi et al., 1999). We find that mGluR- a

• In a recent series of studies from our laboratory to

  2023-12-21

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat ha tag peptide wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induce

• br Concluding Remarks The effects of point mutations

  2023-12-21

  

  Concluding Remarks The effects of point mutations of the four ARs on ligand binding affinities, functional potencies, and efficacies constitute a valuable source of pharmacological information. We analyzed the existing data and mapped it on the collection of available AR crystal structures, allow

16294 records 227/1087 page Previous Next First page 上5页 226227228229230 下5页 Last page