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The putative physiological meaning of epinephrine related he
2024-12-03

The putative physiological meaning of epinephrine-related hepatic drug transporter regulation remains to be established. It is nevertheless noteworthy that the catecholamine rather decreases expression of sinusoidal SLC transporters like NTCP, OAT2, OAT7, OCT1, OATP1B1 and OATP2B1 whereas those of c
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Two patients developed diffuse mesangio
2024-12-02

Two patients developed diffuse mesangio-proliferative glomerulonephritis (DMPG) postoperatively, presenting as nephrotic syndrome and benign haematuria, respectively. DMPG has been reported in an adult patient with thymomatous MG following thymectomy [35], and various types of glomerulonephritis hav
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Language emerged among the Ach through the influence
2024-12-02

“Language” emerged among the Aché through the influence of colonizers, missionaries, Bible translators, activists, anthropologists, the media, and the State. As an object, it now circulates in books, cellphones, political debates, at cultural events, on the radio, and even the Internet. It emerged a
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Later the same group designed
2024-12-02

Later, the same group designed and prepared several Δ16-steroidal C17 benzoazoles and pyrazines and evaluated their CYP17 and 5α-reductase inhibitory activities, binding to and transactivation of the AR, as well as their antiproliferative effects against two human PC cell lines (LNCaP and LAPC4) [18
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Purification of Rv c In order
2024-12-02

Purification of Rv2477c. In order to investigate the catalytic capabilities of Rv2477c, we expressed the protein as an N-terminal histidine-tagged fusion protein in E. coli BL21 cells and purified the protein by cobalt-affinity chromatography. As shown in Fig. 2A, the 65 kDa fusion protein was expre
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In considering the roles of these enzymes in
2024-12-02

In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty A 83-01 synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a surprisin
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It is increasingly evident that many metabolic
2024-12-02

It is increasingly evident that many metabolic genes are associated with cancer progression of various tumor cells, including NSCLC. In particular, GLUT1 overexpression has been reported in NSCLC, and correlations between GLUT1 expression and a number of clinical parameters such as gender, smoking s
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Illustrated in is the protocol we applied
2024-12-02

Illustrated in is the protocol we applied for the screens of novel furoic acids as ACL inhibitors. We constructed our furan carboxylate library that contained 1446 2-furoic autophagy pathway derivatives and 501 3-furoic acid derivatives by performing substructural searches of the ZINC database. W
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The phylogenetic relationship demonstrates that both bovine
2024-12-02

The phylogenetic relationship demonstrates that both bovine and porcine 12/15-LO is more related to the human enzyme than the rabbit enzyme, despite the fact that the rabbit reticulocyte enzyme is a 15-lipoxygenase. The rabbit is one single species that expresses a 12/15 LO with 15-LO activity while
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Introduction Lipoxygenases LOXs are key enzymes that catalyz
2024-12-02

Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic Syringin (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claesson, 200
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In conclusion the partial sequencing and characterization of
2024-12-02

In conclusion, the partial sequencing and characterization of R. quelen cyp19a1b provides essential information about this gene and its presence in peripheral tissues outside of the central nervous system in a teleost. Furthermore, we covered sex differences in the effects of E2 on the cyp19a1b gene
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The neural circuitry involved in
2024-12-02

The neural circuitry involved in the production of the EOD, its modulations, and in the sensory processing of communication signals has been well characterized (Bell and Maler, 2005; Chacron et al., 2011; Krahe and Maler, 2014; reviewed in Metzner, 1999). Pacemaker cells located in the pacemaker nuc
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In order to determine whether the faster
2024-12-02

In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in CGS 21680 depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in contrast to ch
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Later on Wayner Burton Ingold Barclay and Locke modified the
2024-12-02

Later on, Wayner, Burton, Ingold, Barclay, and Locke (1987) modified the method by using lipid to examine the ability of an antioxidant EMD638683 protect against lipid peroxidation generated by azo-compound. It was later improved using β-phycoerythrin (β-PE) as a fluorescent probe, and the ability
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br Materials and methods br Results and discussion
2024-12-02

Materials and methods Results and discussion Conclusion The preparation of acrylic nanoparticles as aminosugar carriers could not be achieved by direct functionalization of poly(t-butyl acrylate) particles with saccharide groups. A four-step procedure starting from a protected derivative of
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