• We noticed that the spontaneous openings of the D R

  2022-04-12

  

  We noticed that the spontaneous openings of the D97R α1 GlyR appeared to be quite similar to those elicited by a maximally-effective glycine concentration on wildtype GlyR; both generated similar open and shut dwell-time histograms, both exhibited openings grouped into clusters with Popen values gre

• With taurine or other molecules that might

  2022-04-12

  

  With taurine, or other molecules that might be transported by Eaat2, an important area of research will be how such a chemical regulates sleep. Indeed, taurine has been described to act on the nervous system in disparate ways — it can act as an inhibitory neurotransmitter, but also has a well-charac

• In glioma or glial derived primary brain tumors as in

  2022-04-12

  

  In glioma, or glial-derived primary 94 8 tumors, as in other cancers, glutathione is an important survival mechanism. Glioma cells are dependent upon SXC-mediated cystine uptake for viability, as they require intracellular cystine/cysteine for GSH synthesis (Ogunrinu and Sontheimer, 2010, Sontheimer

• br Experimental br Results br Discussion

  2022-04-12

  

  Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,

• Congenital Gcgr mice exhibit increased hepatic Fgf expressio

  2022-04-12

  

  Congenital Gcgr mice exhibit increased hepatic Fgf21 expression and circulating FGF21 levels. Previous studies by other investigators demonstrated that neutralization of circulating FGF21 with specific 63 7 impairs glucose control in these mice [6]. In addition, the FGF21 analog LY2405319 lowers blo

• The elective controlled fasting study in our patient provide

  2022-04-12

  

  The elective controlled fasting study in our patient provides further metabolic profiling in patients with GCGR defect. Despite her lean body mass with low weight, at the age of 7 years old she demonstrated a good tolerance for fasting with hypoglycemia MK-4827 mg level, insulin, and counter-regula

• br Acknowledgments br Introduction Postmenopausal

  2022-04-12

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by L002 deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of postme

• Clinical trials of all GSIs have ended

  2022-04-12

  

  Clinical trials of all GSIs have ended prematurely, raising the question on our understanding of their target, the γ-secretase/presenilin. Development of compounds to target γ-secretase and reduce Aβ production is complicated by the fact that γ-secretase/presenilin has critical biological function,

• br Conclusions br Acknowledgments This study was supported

  2022-04-12

  

  Conclusions Acknowledgments This study was supported by funds from the National Natural Science Foundation of China (NSFC 31360245, 31460258) and the Applied Basic Research Foundation of Yunnan Province of China (2011FZ111). Introduction Acute myocardial infarction is the undoubted cause o

• In addition to the robust intracellular calcium mobilisation

  2022-04-12

  

  In addition to the robust intracellular calcium mobilisation, DHA and TUG-891 also induced MMP-9 granules release and superoxide production, supporting a key role of calcium in bovine neutrophil defense responses (Burgos et al., 2011). Pisani et al. (Pisani et al., 2009) described a reduction of bas

• HIV incidence is often determined by following cohorts of HI

  2022-04-11

  

  HIV incidence is often determined by following cohorts of HIV-uninfected individuals and quantifying the rate of new HIV infections. HIV incidence can also be estimated using a cross-sectional study design, using laboratory assays to identify individuals who are likely to have recent HIV infection.

• Dehydroepiandrosterone br Acknowledgments This work was supp

  2022-04-11

  

  Acknowledgments This work was supported by the National Natural Science Foundation of China (31100111), the Nature Science Research Project of Anhui Province (1508085MC43), the subject construction project from Anhui Academy of Agricultural Sciences (14A1110). We would like to acknowledge the tec

• br Histamine H R Many of the highlight

  2022-04-11

  

  Histamine H3R Many of the highlight H3R ligands have been described as suitable pharmacological tools for in vitro or in vivo studies and are designated here. The number of ligands and structural categories is huge, and a number of inclusive reviews of the SAR and properties of H3R ligands have b

• perhaps br Introduction The role of histamine in allergic

  2022-04-11

  

  Introduction The role of histamine in allergic responses, anaphylaxis, and gastric perhaps secretion has been well described in both human and veterinary medicine. New roles for histamine and its receptors, however, have been elucidated over the last two decades (Smuda and Bryce, 2011), and nove

• br Materials and methods br

  2022-04-11

  

  Materials and methods Results Heterologous expression of P. locustae Hxk in methylotrophic yeast P. pastoris was not accompanied by nuclear localization of parasite protein (Fig. 1). The addition of leptomycin B, a specific inhibitor of nuclear export in fission yeast Schizosaccharomyces pombe

16217 records 472/1082 page Previous Next First page 上5页 471472473474475 下5页 Last page