• Michiel S van der Heijden had full access

  2022-01-30

  

  Michiel S. van der Heijden had full access to all amtb data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Wang, Sustic, de Oliveira, van den Heuvel, Bernards, van der Heijden. Wang, Sustic, de Oliveira, van de Ven. Wang, Sustic, de

• The anti platelet functions of ZGR were confirmed

  2022-01-29

  

  The anti-platelet functions of ZGR were confirmed by the mechanistic studies such as the activation of PKC, intracellular Ca2+ mobilization, and the expressions of P-selectin and PAC-1. Further, rivaroxaban prolonged the generation of thrombin and reduced the thrombin burst produced in the propagati

• niacin nicotinic acid The finding that a peptide consisting

  2022-01-29

  

  The finding that a peptide consisting of d-amino acids binds to LSD1-CoREST1 with equal affinity as the l-amino niacin nicotinic acid ligand indicates that the assays detect a generally non-specific association between two highly charged molecules. Nonetheless, p53-CTD is an effective inhibitor of L

• Importantly HDACi mediated effects are cell and HDAC

  2022-01-29

  

  Importantly, HDACi-mediated effects are cell and HDAC specific; different effects and outcomes have been observed in different cell types, targeting different HDAC isoforms. While HDACi exhibit a strong proapoptotic potential in human leukemia TNF-alpha, recombinant rat protein 19, 20, 21, 22, they

• Introduction Epigenetic mechanisms modulate heritable phenot

  2022-01-29

  

  Introduction Epigenetic mechanisms modulate heritable phenotypic changes that are not dictated by changes in DNA sequences. The link between epigenetic modifications and cancer development has been established [1], [2]. Histone modifications represent an important class of epigenetic mechanisms tha

• Here we report the genomic structure and

  2022-01-29

  

  Here we report the genomic structure and the phylogenetic analysis of testis-specific Ser/Thr kinase haspin gene. Materials and methods Results Discussion The isolation and analysis of haspin genomic DNA showed that haspin was an intron-less gene and localized in an intron of integrin αM29

• In diseased blood vessels increased

  2022-01-29

  

  In diseased blood vessels, increased production of reactive oxygen species (ROS), such as peroxynitrite, superoxide, and hydrogen peroxide, have been found [[53], [54], [55]]. Peroxynitrite was suggested to alter the redox state of sGC [53] while hydrogen peroxide interfered with the action of NO bu

• The Scribble complex localizes to the leading edge

  2022-01-29

  

  The Scribble complex localizes to the leading edge in response to integrin engagement. There, Scribble controls the activation Rac and PAK via the Rac GEF β-Pix (Bahri et al., 2010), which is required for collective cell migration (Omelchenko et al., 2014). However, on the rear edge, Scribble can be

• The present studies show that despite the

  2022-01-29

  

  The present studies show that, despite the high level of GSTP1-1 achieved in transfected cells, GSTP1-1 expression has no effect on sensitivities to the cytotoxicities of the oxazaphosphorines 4-OH-CP, 4-OOH-CP, and maf in MCF7 p2x7 antagonist (Fig. 4). The failure of GSTP1-1 to augment resistance

• Glycogen synthase kinase GSK a serine threonine kinase has

  2022-01-29

  

  Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, has been confirmed to be involved in some biological processes in NaCl or wound-treated plants (Chen et al., 2003, Hai et al., 2001, Jonak et al., 2000). NO has been recently recognized as a vital signaling compound in plants. The NO don

• br Materials and methods br

  2022-01-29

  

  Materials and methods Results Human adipocytes, differentiated from fibroblastic preadipocytes in culture, were incubated with IL-33 for either 3 or 24 h to examine acute and prolonged responses to the cytokine. Low, medium and high concentrations of IL-33 were employed. IL-33 had no significa

• GCK MODY is the most common form

  2022-01-29

  

  GCK-MODY is the most common form of MODY diabetes in many populations (Chevre et al., 1998; Massa et al., 2001; Barrio et al., 2002; Estalella et al., 2007; Pruhova et al., 2010; Capuano et al., 2012; Giuffrida et al., 2017). However, data about GCK-MODY among North African populations are very rare

• LbGlcK and the HsHxKIV d glucose

  2022-01-29

  

  LbGlcK and the HsHxKIV-d-glucose complex (PDB entry 3IDH) [17] were superimposed from individual subunits. The active site regions revealed the key L-NMMA citrate binding residues to be present for LbGlcK; also, the superposition showed that HsHxKIV had residues that were absent in LbGlcK, such as

• The MeO CFO phen yl group

  2022-01-29

  

  The 1-MeO-4-CFO-phen-2-yl group was then selected for the C-3 position when we investigated the aryl substituents at the C-6 position of indazole. As shown in , C-6 position seems to be more tolerant than the C-3 position, as all the aryl groups examined exhibited potent hGCGR activity. Interestingl

• When we compared the effects in FST

  2022-01-29

  

  When we compared the effects in FST induced by GAL and GAL(1–15), we observed that the increase in the immobility induced by GAL(1–15) was significantly higher than the one induced by GAL (Millon et al., 2015). Moreover, in climbing behaviour, GAL(1–15) also induced a stronger decrease in climbing r

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