• Because FPR is expressed in VSMCs and its role

  2021-09-10

  

  Because FPR-1 is expressed in VSMCs and its role in non-hematopoietic cells is still unclear, we questioned whether FPR-1 would have physiological relevance for vascular behavior, in the same way as it does in neutrophils (Ca2+ homeostasis and angiogenic polymerization). First, we tested if FPR-1 i

• gap 27 br Introduction Fructose bisphosphatase FBPase EC

  2021-09-10

  

  Introduction Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) catalyses the irreversible reaction of hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate [1]. Genetic and kinetic studies so far have demonstrated that at least two distinct isoenzymes of FBPase e

• Neuropathic pain NP is a

  2021-09-10

  

  Neuropathic pain (NP) is a chronic pain caused by lesion or disease affecting any part of the nervous system leading to clinical conditions ranging from painful neuropathy to poststroke central pain. Anticonvulsant drugs, Gabapentin and Pregabalin, acting on αδ subunit-containing voltage-dependent c

• br Acknowledgments I thank Takeshi Sakaba for critical readi

  2021-09-10

  

  Acknowledgments I thank Takeshi Sakaba for critical reading of the manuscript and helpful comments. This work was supported by JSPS/MEXT KAKENHI Grant Numbers 17K19466, 17H03548. Introduction The oral route of drug application is the main route in pharmacology since it is easy to handle and o

• br Formation of secretory vesicles and trafficking toward pl

  2021-09-10

  

  Formation of secretory vesicles and trafficking toward plasma membrane Insulin and other components of the secretory granules are sorting and providing certain cues for Idoxuridine off the adjacent TGN membrane, forming immature secretory clathrin coated vesicles (Gehart and Ricci, 2013). Bin/Am

• It is apparent from the data in that none of

  2021-09-10

  

  It is apparent from the data in that none of the ligands exhibits significant toxicity as determined by the viability of human embryonic kidney (HEK 293) cells at a concentration of 100 μM. It is also apparent from the data in and that a number of the ligands inhibit the HIV-1 IN enzyme. However,

• Fig summarizes the results for M concentration of

  2021-09-10

  

  Fig. 1 summarizes the results for 500 μM concentration of the drugs. Action of histamine is presented for comparison. Both 1-methylhistamine and Nα-methylhistamine strongly potentiated ASIC1a responses. The concentration-dependence of action of Nα-methylhistamine was measured (Fig. 1B). Fitting by H

• Arena Pharmaceutical introduced a biaryl sulfone derivative

  2021-09-10

  

  Arena Pharmaceutical introduced a biaryl sulfone derivative with antagonistic activity at H3Rs known as APD-916, ((R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine), which was rationally designed from corresponding sulfonamides in order to yield compounds with short dura

• Although we showed that RBL H Sc cells

  2021-09-10

  

  Although we showed that RBL-2H3 Sc98 mu opioid receptor antagonist took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter fam

• It is difficult however to assure that observed alterations

  2021-09-10

  

  It is difficult, however, to assure that observed alterations of pro-oxidant/antioxidant levels within the studied organisms are related directly to heavy metal pollution, rather than to other accompanying environmental stressors. Environmental factors like oxygen partial pressure, temperature, sali

• The isoenzyme hGSTP is an attractive drug target

  2021-09-10

  

  The isoenzyme hGSTP1-1 is an attractive drug target due to its high levels of disease association (target validation) and druggability (target tractability) properties [5,6,[17], [18], [19], [20], [21]]. hGSTP1-1 functions as a homodimer protein [18]. Each monomer has two domains, an α/β domain (N-t

• Cichlasoma dimerus as most teleost fish species present

  2021-09-10

  

  Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most FPH2 species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and the POA (González-Martí

• br Results br Discussion br Materials and

  2021-09-10

  

  Results Discussion Materials and Methods Introduction Deoxyribonucleic Sodium Aescinate (DNA) is among the most important biopolymers in living organisms alongside carbohydrates and proteins. DNA is a linear polymer consisting of four types of nucleobases, deoxyribose, and phosphate. Th

• Similarly both neofunctionalization and subfunctionalization

  2021-09-09

  

  Similarly, both neofunctionalization and subfunctionalization likely occurred for the duplicated proglucagon genes. The change in function of GLP-1 would be a neofunctionalization, however in this case it acquired a redundant function – a function that largely overlaps with glucagon effects in the l

• br Lung cancer cell lines The greatest expression

  2021-09-09

  

  Lung cancer cell lines The greatest expression of both human and rodent FFA4 transcript has been shown to be localized to the lung [61], yet the physiological role in this tissue has been understudied, as has its involvement in lung cancers. In 2015, a two-staged genome-wide association study of

16158 records 595/1078 page Previous Next First page 上5页 591592593594595 下5页 Last page