• In summary it is clear that the

  2018-11-05

  

  In summary, it is clear that the Late Cretaceous is a major episode of magmatic activities and the related large scale Sn–W mineralization distribute throughout the southeast Yunnan and northeast Vietnam. Combining the new data of this study and published igneous rocks and mineralization ages (Appen

• The current study must be interpreted within

  2018-11-05

  

  The current study must be interpreted within the context of its strengths and potential limitations. A strong point is that we measured both dp-ucMGP and t-ucMGP in a relatively large sample representative of the Flemish population and that we replicated the inverse association of eGFR or chronic ki

• br Results RNA analysis was

  2018-11-05

  

  Results RNA analysis was carried out on 361 NF1 affected individuals who fulfilled NIH criteria with at least one non pigmentary criterion. Twenty one familial cases with just pigmentary NIH criteria were excluded (14 NF1 mutations (12 missense mutations); 7 SPRED1 mutations). One hundred and sev

• Several conflicting large scale population based studies

  2018-11-05

  

  Several conflicting large-scale population-based studies published recently (e.g. (Lau et al., 2015; Moriya et al., 2015; Tsunoda et al., 2014)) indicated that myd88 inhibitor moderate (or ‘non-alcoholic’) alcohol consumption either has a beneficial or detrimental association with prevalence or dev

• br Materials and Methods br Results br

  2018-11-05

  

  Materials and Methods Results Discussion Although aberrant glycosylation is common in cancer and has been linked to PCa progression (Munkley et al., 2016), our understanding of what drives these cancer associated glycan changes has been scant and has relied upon anecdotal observations. Here

• In addition to classical receptor targets such as

  2018-11-05

  

  In addition to ‘classical’ receptor targets such as EGFR (Roovers et al., 2007,2011; Schmitz et al., 2013; Omidfar et al., 2013), HER2 (Jamnani et al., 2012; Even-Desrumeaux et al., 2012), c-MET (Slordahl et al., 2013) and VEGFR (Behdani et al., 2012), nanobodies against new targets such as the DR5

• br Materials and methods br Results br Discussion

  2018-11-05

  

  Materials and methods Results Discussion In the search for drugs for human prion diseases, we conducted docking simulation using a DEGIMA supercomputer. Results from the in vitro and ex vivo drug screening revealed that NPR-053 and -056 significantly reduced PrPSc levels (Figs. 2 and 5). Al

• Although there is no clear association between narcolepsy an

  2018-11-05

  

  Although there is no clear association between narcolepsy and PLMs, some studies demonstrated the important role of hypocretin-1 in this ret pathway association . Alteration of the autonomic regulation, sleep fragmentation and increase in the PLMs prevalence might be present in patients with narcole

• Much work has been done previously in community

  2018-11-05

  

  Much work has been done previously in community-dwelling older adults on the relationship between the level of physical activity and sleeping. These studies have involved direct comparisons between physically fit and unfit groups [6,7], cross-sectional observational studies [8–11], and randomized co

• The most frequent reasons for indication of RP were

  2018-11-05

  

  The most frequent reasons for indication of RP were: snoring (76%), observed apneas (32%), sleepiness or poor sleep quality (74%), and snoring associated to arterial lipid metabolism pathway (AHT) 41% (Fig. 1). The Fig. 2 shows distribution according to anthropometric parameters. The polygraphic i

• The physiology of sleep wakefulness cycle may be

  2018-11-05

  

  The physiology of sleep-wakefulness pri-724 may be affected as a result of changes in ovarian hormone synthesis. The menopause and the reduction in the availability of endogenous estradiol, that occur within the climacteric, have been considered risk factors for SD. The effect could be directly infl

• br Discussion CPAP therapy has been considered the gold stan

  2018-11-05

  

  Discussion CPAP therapy has been considered the gold standard for treatment of OSAS in adults. However, despite the success potential of CPAP, non-adherence by patients remains a major problem [9]. Some publications have been critical regarding surgeries and their results [10]. Elshaug et al. (20

• In spite of the large

  2018-11-05

  

  In spite of the large number of assumptions made, both for calculation of the biofilm volume fraction in the resonator and for the model simulations, Fig. 13 clearly demonstrates that, in case of biofouling on the glass beads, the measured sensor response (shift in AF plot) is in the same direction

• br Conclusions In summary novel SERS active substrates were

  2018-11-05

  

  Conclusions In summary, novel SERS-active substrates were prepared by inert gas phase condensation technique using a Nanodep60 cluster deposition system. We used 2-Thienylboronic HMBA Linker as linker or bridge molecule that attached to the silver surface on one side and to the glucose molecule

• Oxysterols serve as endogenous ligands of liver

  2018-11-03

  

  Oxysterols serve as endogenous ligands of liver X receptors (LXRα (NR1H3)/LXRβ (NR1H2)) (Janowski et al., 1996). In addition to their established role in cholesterol metabolism (Janowski et al., 1999), LXRs also suppress inflammatory gene expression, thus controlling immune response and inflammation

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