• Cepharanthine: Bridging Apoptosis Research and Endometriosis

  2026-07-27

  Cepharanthine, a biscoclaurine alkaloid, is rapidly emerging as a focal molecule in both mechanistic and translational research for chronic gynecological diseases. This article unpacks its dual role as an apoptosis inducer and immunomodulatory agent, synthesizing new evidence from organoid and in vivo models of endometriosis. We provide practical guidance for experimental design, compare Cepharanthine to current standards, and chart a forward-looking roadmap for researchers seeking high-efficacy, low-toxicity therapeutic options.

• Pomalidomide (CC-4047) in Hematological Malignancy Research

  2026-07-26

  Pomalidomide (CC-4047) stands out as a precision tool for dissecting tumor microenvironment dynamics and drug resistance in multiple myeloma models. This article translates recent mutational landscape insights into actionable workflows, protocol optimizations, and troubleshooting strategies for applied hematological malignancy research.

• Ferritin Hybrid Protein Particle Vaccine: Influenza A & SARS

  2026-07-25

  This study presents a ferritin-based hybrid protein particle vaccine combining the M2e antigen of influenza A with tandem S protein epitopes from SARS-CoV-2. The approach demonstrates enhanced immunogenicity and protective potential, offering a promising platform for next-generation combination vaccines.

• Redefining In Vitro Drug Response Metrics in Cancer Research

  2026-07-24

  Schwartz (2022) introduces a paradigm-shifting in vitro methodology for evaluating anti-cancer drug responses, distinguishing between proliferative arrest and cell death. This nuanced approach enhances preclinical assay interpretation, shaping how angiogenesis inhibitors like Cediranib (AZD2171) are assessed in cancer research.

• Entinostat (MS-275): Mechanistic Insight for Translational O

  2026-07-24

  Explore how Entinostat (MS-275) reshapes translational cancer research by bridging advanced mechanistic understanding with actionable guidance for in vitro and in vivo workflows. This article highlights Entinostat's selective HDAC1/3 inhibition, the nuanced evaluation of anti-cancer drug effects, and strategic considerations for researchers aiming to optimize epigenetic therapies.

• Cyclic di-GMP: Bridging Bacterial Persistence and Immune Mod

  2026-07-23

  Discover how cyclic di-GMP, a key intracellular second messenger, orchestrates both bacterial biofilm resilience and immune modulation. This article uniquely explores the mechanistic cross-talk between microbial persistence and STING-driven immunity, offering actionable insights for advanced research.

• Targeting Hippocampal CA2: AAV/M1-Cre as a Precise Research

  2026-07-23

  Peng et al. introduce a novel AAV/M1-Cre vector leveraging the mini Map3k15 promoter for highly specific labeling and manipulation of hippocampal CA2 neurons in mice. This advancement addresses a longstanding technical bottleneck, enabling finer dissection of CA2's roles in memory and social cognition.

• Radicicol: Mechanistic Insights for Precision Adipogenesis a

  2026-07-22

  Explore the multifaceted role of Radicicol as a potent Hsp90 inhibitor, delving into its molecular mechanisms and unique applications in adipogenesis and inflammation research. This article offers a distinct, in-depth analysis that advances beyond standard protocols.

• Mutational Landscape of Myeloma Cell Lines: Drivers and Drug

  2026-07-22

  A recent exome-wide analysis of human multiple myeloma cell lines revealed both established and novel mutational drivers, mapping pathways that influence tumor progression and drug resistance. This work provides a molecular framework for selecting relevant in vitro models and informs strategies for therapeutic targeting in hematological malignancy research.

• Etomoxir in Immune Metabolism: Deep Dive into Standardized A

  2026-07-21

  Explore how Etomoxir, a potent CPT-1 inhibitor, is transforming immune metabolism research through standardized whole-blood assays. This article provides advanced scientific insight into assay design, highlighting novel protocol innovations and practical guidance for leveraging Etomoxir in immunometabolic studies.

• STING agonist-1 in Immunology: Protocols & Troubleshooting

  2026-07-21

  STING agonist-1 enables precise dissection of STING pathway signaling in innate immunity, B cell activation, and cancer immunotherapy. Combining high purity, robust DMSO solubility, and translational validation, this APExBIO reagent is essential for reproducible, advanced immunology workflows.

• PDK4-IN-1 Hydrochloride: Precision Modulation of PDH Signali

  2026-07-20

  Discover how PDK4-IN-1 hydrochloride, a selective pyruvate dehydrogenase kinase 4 inhibitor, enables advanced regulation of mitochondrial energy metabolism and the glycolysis–TCA cycle. This article offers new scientific insights and assay guidance beyond standard protocols.

• Perospirone Inhibits Kv1.5 Channels in Coronary Arterial Cel

  2026-07-20

  A recent study reveals that perospirone, an atypical antipsychotic, inhibits vascular Kv1.5 potassium channels in coronary arterial smooth muscle cells—a novel off-target effect. These findings expand the mechanistic understanding of perospirone and highlight the need for careful consideration of cardiovascular impacts in both clinical and research applications.

• Baicalin: Mechanistic Advances in Visual Plasticity and Onco

  2026-07-19

  Explore how Baicalin modulates KEAP1-NRF2/HO-1 and TGF-β1/p-Smad3 pathways, revealing new insights for visual plasticity and cancer research. This article delivers a unique, in-depth analysis of Baicalin's translational potential, grounded in the latest scientific evidence.

• Everolimus (RAD001) in Cancer Research: Protocols & Pitfalls

  2026-07-18

  Everolimus (RAD001) enables precise mTOR pathway inhibition in cancer biology, supporting advanced apoptosis and proliferation workflows. This article details experimental setups, troubleshooting strategies, and innovations leveraging APExBIO’s Everolimus for robust, reproducible results in both in vitro and in vivo research.

8364 records 4/558 page Previous Next 12345 下5页 Last page