• In order to determine whether

  2025-02-26

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in myelin basic protein depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in co

• To further address the mechanism of Didox s suppressive effe

  2025-02-25

  

  To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor J5 epigenetic research tool and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must b

• br Results Four HT esters

  2025-02-25

  

  Results Four HT esters (butyrate, caprylate, laurate and stearate esters) were chosen as representative compounds of increasing lipophilicity (Fig. 1). We will refer to them as C4HT, C8HT, C12HT and C18HT, respectively. They have been synthesized, purified and characterized according to our previ

• br Genetic analysis of polarity complexes Model organisms

  2025-02-25

  

  Genetic analysis of polarity complexes Model organisms such as Caenorhabditis elegans and Drosophila melanogaster provide useful means of describing basic biological processes. They lend themselves particularly well to addressing some of the questions arising in this field because of their struct

• Introduction Heterotrimeric G proteins mediate signal transd

  2025-02-25

  

  Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s

• br Acknowledgments and Disclosures br Alzheimer

  2025-02-25

  

  Acknowledgments and Disclosures Alzheimer's disease as a synaptic pathology Alzheimer's disease (AD) is a chronic neurodegenerative MLN 2480 disorder and the most common cause of dementia in the elderly. Progressive depositions of amyloid plaques and neurofibrillary tangles together with dege

• br Results br Discussion Many tumor cells rely on

  2025-02-25

  

  Results Discussion Many tumor T-5224 rely on EAAs to provide fundamental building blocks for macromolecular biosynthesis because they cannot synthesize EAAs de novo (Hattori et al., 2017; Sheen et al., 2011). Therefore, they must use highly effective transporters to maximize EAA uptake from t

• An important and well documented pathway involved in cellula

  2025-02-25

  

  An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate

• br Materials and methods br Results br Discussion In the

  2025-02-25

  

  Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi

• Adiponectin also suppresses inflammatory stimuli induced NF

  2025-02-25

  

  Adiponectin also suppresses inflammatory stimuli-induced NF-kappaB activation, which may significantly contribute to the anti-diabetic and anti-atherogenic effects of adiponectin (Ouchi et al., 2000). The downstream mediators of AdipoR1 and AdipoR2, RPPAR and AMPK increase inflammatory responses by

• Derivatives of M that possess either an

  2025-02-25

  

  Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these Selective 5-HT1 agonist to maintain 5-HTR antagonist properties as (+)-M100907

• If overexpression of ADK is

  2025-02-25

  

  If overexpression of ADK is sufficient to induce spontaneous seizures, then reduction of ADK in engineered mice should prevent epileptogenesis. The generation of mice with moderately reduced levels of ADK in brain rather than complete ADK deficiency seems to be essential, since several lines of evid

• Recently biosensors based on enzyme mimicking organic inorga

  2025-02-25

  

  Recently, biosensors based on enzyme-mimicking organic-inorganic hybrid nanomaterials such as protein or DNA-Cu nanoflowers (Batule et al., 2015, Park et al., 2017), Fe-aminoclay (Lee et al., 2013), and MOFs (Ai et al., 2013, Dong et al., 2015, Feng et al., 2012, Liu et al., 2013, Qin et al., 2013,

• A review has recently been published to evaluate

  2025-02-25

  

  A review has recently been published to evaluate the potential effects of food, alcohol and PA-824 juices on the pharmacokinetics and pharmacodynamics of the drugs for BPH. The authors reviewed the PubMed database during the years 1991–2015. In addition, a digital version of Stockley on drug intera

• Conclusion Twenty compounds with dinitrobenzoate scaffold we

  2025-02-25

  

  Conclusion Twenty compounds with 3,5-dinitrobenzoate scaffold were synthesized and evaluated using cell-free and HWB assays for their 5-LOX inhibition activities. Compared to the parent compound, six compounds show significantly increased enzyme inhibition activities. The best compound, 3-tolyl 3,5

16117 records 5/1075 page Previous Next 12345 下5页 Last page