• The product chain length determination mechanism of prenyltr

  2022-01-03

  

  The product chain-length determination mechanism of -prenyltransferases has not yet been elucidated, although mutational analyses of highly conserved residues and of characteristic amino cc-5013 residues in each subfamily of -prenyltransferases have enabled the understanding of the basic catalytic m

• To address this we developed approaches to image at

  2022-01-03

  

  To address this, we developed approaches to image at high spatial and temporal resolution live WPB fusions as well as the release of VWF and other WPB cargo by spinning disk microscopy and combined laser ablation and total internal reflection fluorescence (TIRF) microscopy. Our live cell imaging rev

• As an inflammatory mediator histamine plays a pivotal role i

  2022-01-03

  

  As an inflammatory mediator, histamine plays a pivotal role in nociceptive processes in both the central and peripheral nervous systems (Gemkow et al., 2009; Hough & Rice, 2011; Tiligada et al., 2009). In this respect, the participation of H3Rs in modulating pain, especially neuropathic pain, has at

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